The Role of p53 in Cancer

Maja Divjak
Maja Divjak
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Published 2020-03-01
p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely bind to the critical site. This means no decisions can be made about whether to repair DNA or destroy the cell. Without functional p53, cells can accumulate more and more DNA damage, possibly leading to cancer.
All Comments (21)
  • @kanetao
    That rattle! I will never imagine DNA without that sound again.
  • @PatientsPortal
    I just visited my friend in hospital day 36 at UCLA, who has the P53 mutation and Diffuse Large B-Cell Lymphoma (DLBCL). Seeing her strength firsthand, despite her white blood cell count being at 0.9, has been incredibly inspiring. It's true what they say: the best teacher is learning from a patient. My friend is the most resilient person I know, and their journey is a powerful reminder of the strength and courage in the face of adversity.
  • @yunxizha2276
    I have my finals today. I never understood 053 throughout the semister. You helped me so much. THANKYOU!!!
  • @marlondavid1108
    I’m from Germany and I’m 16 years old and no teacher in my school and no German video could help me more than you! Thank you now i understand :)
  • @peters972
    What a great video! It’s not that often I find out something new these days there is quite a lot of recycling. But this was new to me! Thank you.
  • @nightmaregamer3711
    Just what I was looking for. Great video; informative narration and superb visuals 🧬
  • @randjietsingh
    Extremely well explained. I did my minor on this subject. Also your vid sound like the inside of Starcraft Zerg hive, which makes it extra cool!
  • @EzioAuditore
    Wow such an amazingly well done presentation , great work!
  • @kamendinand7
    This is so well made and easy to understand. Thank you soo much for helping my study 🙏🙏
  • @israelfernhill
    Loved the video! Any chance that you guys could add the source of the information?
  • @arturlyaptyap4926
    The 21st century and scientists cannot figure out how to fix this gene so that the body can kill cancer cells itself. I have this gene and I have cancer and I want to be healthy