Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

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2024-02-19に共有
In this episode, my guest is Dr. Mark D'Esposito, M.D., a neurologist and professor of neuroscience and psychology at the University of California, Berkeley. We discuss the brain mechanisms underlying cognition and the forms of memory required for focus, productivity, planning and achieving goals, and learning. We discuss neurochemicals such as dopamine and acetylcholine and how they can be leveraged to improve cognitive functioning. We also discuss concussion, traumatic brain injury (TBI), Alzheimer's, and Parkinson's disease, and ways to restore or slow cognitive decline by using pharmacologic, lifestyle and behavioral protocols. This episode provides a modern understanding of cognition and memory and actionable tools to optimize brain health and function.

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Dr. Mark D'Esposito
Academic profile: bit.ly/49wwPMo
Lab website: bit.ly/3I4Sxev
BrainHealth project: bit.ly/3SEiZ3w
Publications: bit.ly/3T4AH1J
X: twitter.com/mtdespo

Journal Articles
Cognitive and attentional mechanisms in delay of gratification: bit.ly/49zpHPL
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control: bit.ly/3UdfWBP
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey: bit.ly/4bBqMI9
Clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”: bit.ly/42IuviW
Estrogen Shapes Dopamine-Dependent Cognitive Processes: Implications for Women's Health: bit.ly/42G4xwF
Ongoing dynamics in large-scale functional connectivity predict perception: bit.ly/3SMFT92

Other Resources
BrainHQ: bit.ly/3I6y5d6
The BrainHealth Project: bit.ly/3I591Dm
Neuroscouting: bit.ly/42IpZB8

Huberman Lab Episodes Mentioned
Nicotine's Effects on the Brain & Body & How to Quit Smoking or Vaping: go.hubermanlab.com/GpyRhoQTYT
Tools to Enhance Working Memory & Attention: go.hubermanlab.com/s7LQP1bsYT
Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep: go.hubermanlab.com/psVAPrDqYT
How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks: go.hubermanlab.com/ggl7TvJuYT

People Mentioned
Brian Levine: Professor Dept. of Psychology, University of Toronto: bit.ly/49h05qz
Matthew Walker: Professor of Neuroscience & Psychology, UC Berkeley: bit.ly/3UK2Ags
Michael Merzenich: Professor Emeritus - Neuroscience, USCF: bit.ly/3T4rSoD
David Hubel and Torsten Wiesel: Nobel Prize (1981): bit.ly/3T6SPYQ
Emily Jacobs: Associate Professor of Psychology, UC Santa Barbara: bit.ly/3T0AaOa
Art Kramer: Professor Emeritus, University of Illinois Urbana-Champaign: bit.ly/48l4982
Eddie Chang: Professor of Neurological Surgery, UCSF: bit.ly/3SLsjmd
Karl Deisseroth: Professor and Psychiatrist, Stanford: stanford.io/49BQmuG
Sepideh Sadaghiani: Associate Professor of Psychology, University of Illinois Urbana-Champaign: bit.ly/48CagoF

Timestamps
00:00:00 Dr. Mark D’Esposito
00:02:08 Sponsors: Maui Nui, Joovv & Eight Sleep
00:06:23 Brain & Frontal Lobes, Prefrontal Cortex, Executive Function
00:10:31 Frontal Lobe Development, Children
00:14:12 Rules, Context & Impulse Control; Learning & Goals
00:21:45 Focus, Improving Executive Function
00:26:04 Connections & Top-Down Signals
00:29:02 Sponsor: AG1
00:30:29 Frontal Lobe Injury; Emotional Regulation
00:37:26 Smartphones, Social Media
00:44:37 Working Memory, Dopamine
00:52:59 Sponsor: LMNT
00:54:22 Dopamine Levels & Working Memory, Cognitive Tasks, Genetics
01:00:03 Bromocriptine & Working Memory, Dopamine
01:06:21 Guanfacine, Neurotransmitter Levels, Pupil Dilation & Biomarker Tests
01:12:46 Bromocriptine, Olympics; Pharmacology & Cognitive Function, Adderall
01:19:27 Concussion, Traumatic Brain Injury (TBI)
01:25:22 Sleep, TBI, Concussion & Executive Function; BrainHQ
01:31:57 Aging & Frontal Executive System; Brain Health
01:39:26 Tools: Brain Health & Boosting Executive Function, Books
01:47:26 Alzheimer’s Disease, Genetics, Pharmacology
01:51:48 Parkinson’s Disease, L-Dopa; Coping with Alzheimer’s; Nicotine
01:58:37 Estrogen & Dopamine, Cognition; Tool: Physical Exercise
02:04:43 Tool: Mindfulness Meditation & Executive Function
02:10:31 Brain Networks; Modularity
02:17:08 Modularity, Brain Indices
02:22:53 Psilocybin; Transcranial Magnetic Stimulation
02:30:16 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

#HubermanLab

Disclaimer: www.hubermanlab.com/disclaimer

コメント (21)
  • @bent7190
    An episode about skin health would be great
  • @Niloufarsaber
    ‏Dr. Huberman, I just wanted to take a moment to express my deep admiration and appreciation for your exceptional work. Since the day you launched your podcast, I have been an avid listener, eagerly absorbing the valuable insights and wisdom you share. Your ability to articulate complex concepts in a clear and engaging manner is truly remarkable. In fact, I have dedicated a special notebook solely for jotting down the profound ideas, quotes, and thoughts you express during your podcast episodes. Your passion for your work shines through in every episode, and your commitment to sharing knowledge and empowering others is truly commendable. The impact you have had on my personal and professional growth is immeasurable. Thank you once again for your remarkable work. You have truly made a positive impact on my life, and I am grateful for the opportunity to learn from someone as knowledgeable and inspiring as you. Niloufar from Iran
  • What changed my cognitive to the fullest was the utilization of focused vision (like manually telling yourself to focus on what you see and not wander off) and being in the present moment (to the point of telling yourself that past and present is an illusion). It's like a superpower!
  • @sambadi782
    An episode about brain damage would break the internet. Concussions and how they affect people in general, martial artists etc. A topic not spoken enough of.
  • It might just be a short snippet, but that little bit about estrogen and dopamine is information I’ve been looking for for 15 years! My hormones have been wreaking havoc on my cognitive functioning for a very long time to the point where I am barely functional. I’ve still got a long way to go to get my life back, but this is a major piece of the puzzle! Thank you for having conversations with experts that we don’t the ability to converse with ourselves, and helping us understand the latest research!
  • Dr.H - I studied Polysomnography, and your content has expanded my knowledge on the brain and how it works. I love your podcast. Youre a blessing to all. May God continue to bless you.
  • As an adult female of a certain age who wants to retain as much cognitive function as possible this was insightful. I'm keeping my brain active by taking up new tasks, languages, a musical instrument and still doing online games, covering memory, focus and enjoying every minute of these podcasts so thank you for the knowledge you impart.
  • Super excited about this episode! As a cancer (chemo) survivor who still struggles 10yrs later with memory issues from it plus lifelong ADHD I love these kinds of episodes! ❤️
  • Dr. Huberman, Your recent episode on "Optimizing Cognitive Function and Brain Health" deeply inspired me. As someone who sustained a traumatic brain injury (TBI) at the age of five during a mountain accident and is currently navigating college with ADHD, I find immense value in your insights. As a science major, I face significant academic friction, yet your podcast offers practical strategies that resonate with my circumstances. Your dedication to neurobiology and brain health improvement is profoundly motivating, and I am eager to apply your recommendations to manage my TBI and ADHD symptoms better. Thank you for your impactful work, which serves as a beacon of hope for individuals like myself striving to overcome neurological challenges and achieve academic success. Warm regards, Drew
  • No mention of the "The End of Alzheimer's" books by Dr Dale Bredesen. It is working for me after repeated head traumas over most of my 66yrs. Your dawn/sunrise walks out in the countryside were a gamechanger for me. thank you.
  • @HavarNamar
    First thing on Tuesday morning (Mongolian timezone), I directly go to Huberman Lab podcast with a lot of excitement. Thank you so much for making our lives much better!
  • Strong work with this one, and truly all of them. Just a thought- would you ever consider an episode on longevity/ wellness for people in high stress and 24-hours-a-day working environments? Personally, I am a paramedic and a mountain guide, but, I imagine many of your listeners are military, nurses, police, emergency physicians, etc. Any lifestyles that it is hard to optimize the pillars of mental and physical health. I see many colleagues suffer and compensate poorly which in turn affects patient outcomes, empathy, etc. I believe such an episode could benefit not only frontline workers and our ability to sustain a career that we love, but it would also have massive trickle down effects to patients, families, healthcare systems, justice systems, and society as a whole. Rock on
  • @justin.baer_
    Thank you very much for your work, Andrew Huberman!
  • Dr. Huberman, please accept my sincere appreciation of your continuous efforts regarding this podcast. I would never be able to approach the nonstop-evolving negative complexity of my life circumstances without the language base I primarily build with your unintentional involvement. English vocabulary by itself creates enormous barrier for post-graduates being marginalized by emigration. The use of it - is another level of an issue which explodes by frontal lobes impairment caused by spousal mistreatment and psychological abuse. If not for your consistency I would have no example of normality. No pattern of speech to measure my adequacy by on certain topics. Thank you. Please, be and do ..as you are 😊
  • @SD-kp6fj
    Thank you for making these podcasts available for those who simply want to learn. Your uploads are greatly appreciated Dr. Huberman.
  • I found your podcasts a month ago. Putting as much as I can into action has been a real life changer. Thanks
  • @keo1221
    I'm 5 years post injury, fainted and fell onto the back of my head. I look pretty normal until I'm not. can go from speaking normal to not finding words or getting them out, balance can get wonky if too tired or in a busy and loud environment. Thank you for talking about PPCS! It's not understood by most docs, and that goes for most neurologist s. Brain training has helped me relearn simple math, spelling and improve memory. You could devote an entire episode on mTBI, such as how age, number of previous TBIs, being female, hx of migraines all affect the rate of recovery. Thank you so much for all your good work.
  • @iamskaars
    My brain got healthier just seeing the notification of this episode 🔥
  • @TraciC23
    Thanks for this! I always appreciate neurology-based episodes. That said, I'd love to see an episode of how TBIs can affect vision and the treatments to fix the resulting issues (asking for a friend) and/or one on functional disorders, such as Functional Neurological and Functional Cognitive disorders. Thank you!