028 - New findings: more evidence of poor oxygen perfusion in the brain.

Erratum #1: It was noted in the comments below that it is inaccurate to say mitochondria need ATP to function. They have other sources, such as pyruvate, to perform their basic functions. It is instead correct to say that mitochondria produce ATP, which is then used by cells. Erratum #2: I misspoke and said "oxygen" instead of "lactate" at 5:59. Thanks! - Jarred Younger

Omg, I hang on every video! I kept going, "wait WUT?!?!" and rewinding! I feel like all the pieces are coming together in your work! I'm so grateful that you make these videos!

These tidbits are great. Everyone sideeyed me when I'd say my fatigue was mitochondrial-related. Too bad I have no interest in putting in the work to do research because if I did, I'd totally want to have you as a professor and look into such important topics that affect so many. I really appreciate how you aspire to actually help people with your research. You're awesome 😎

In case you aren’t aware, the University of Zürich is doing a Long Covid study with pycnogenol.

Gotta say I love seeing how excited you're becoming. With each successive video, you're becoming more and more energised. It's obvious that you love your job and it's a real joy to listen and learn along with these videos. Thanks for all you and your team do.

Everything revolves around cellular hypoxia. This is also shown on a 2 day CPET for ME. Many years ago Dr David Bell said ME is like a low level sepsis & cell hypoxia. This occurs in the brain and body wide. Definitely the crux of this whole problem & disease. The harder issue is what is the cause of this? What’s upstream of this? Is it an uptake issue via Mito probs or delivery prob (capillary issue?) or something else. Very complicated but the research should be focusing here. I had a 2 day cpet (I have severe ME) and was in an anaerobic state even at rest. Ty for your work here

Excellent update. Extremely excited for all the news to come!

Excellent! This explains how my long cov, past mold, celiac, sibo, gut dysbiosis, , sars in michchondria, stops energy production, + cause the multiple organs dysfunction I live w in daily agony.. this info needs to go to all Drs , interns, , re education, dr Paul. Anderson+ Dr David putrino, would concur with you, 🙏❤️

I look forward to hearing more. Thank you! I was fascinated to learn recently that Michael Phelps is reported to produce the smallest amount of lactic build-up than other elite athletes. Has there been any studies with these elite athletes as healthy controls? It doesn't seem like it's training alone. There is a lot of discussion on choline in the Alzheimer's space. Really fascinating and intriguing!

great new informations; thank You!

Huperzine can boost the muscarinic aspect of choline and nicotine patch the nicotinic aspect of acetylcholine. Also acetyl L carnitine is a precursor to choline. Thanks for the update

Great video thank you. I've been testing my lactase at home over the last 18 months. It is often elevated and it relates to PEM (I have post viral me/cfs). Basically any small exertion leads to an increase in lactate and then post exertional malaise. I just have a finger prick blood test monitor. Very soon the are relasing 24 hour lactate monitors. I believe that lactate monitoring will perhaps do for me/cfs patients what glucose monitoring does for diabetics.

Dr, have you heard of UK physician Raymond Perrin, & his thoughts on the lymphatic system m of ME/CFS, post viral syndrome?alfunctioning, as the origin? I have severe ME/CFS. I used to be a “junior” research scientist. I’ve been looking for answers for 10 years. I think he’s also onto something. There are peer reviewed papers supporting it. He has a technique called, The Perrin technique. Thank you for all you and your team, including Chloe for your dedication.

So, there are some doctors who use NAD shots to treat mitochondrial function in long covid. I've heard of a lot of success with this. The only down side is the only insurance company that will pay for it is medicare. What are your thoughts on NAD shots to treat this problem?

This is such important work. Thank you for sharing. 🙏

Have you ever considered people with sleep apnea as those to test for poor oxygen perfusion to the brain? I know that if my sinuses are stuffed my cpap machine doesn’t work and I get a bad migraine the next day. I also have horrible fibromyalgia and chronic fatigue.

The only issue with choline is it can cause cardiovascular disease. Lots of studies on that. However if you are taking it for ME/CFS or Long Covid it may help, but be aware not to stay on it for years on end. I tried it for several months, unfortunately with no improvement whatsoever.

Acetylcholine deficit in ME has been known for decades.

As always, fascinating! Thank you! 😊

Thank you Jarred, good information.