Saturated Fat with Dr. Ben Bikman

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Published 2024-05-07
In this episode of The Metabolic Classroom, Professor Ben Bikman, an expert in metabolic research, discusses the debate surrounding saturated fat and its impact on insulin resistance.

Dr. Bikman addresses misconceptions about saturated fat perpetuated by proponents of plant-based diets, who often blame meat-based saturated fats for insulin resistance. He refers to his own 2011 research, highlighting the role of toll-like receptor four (TLR4) activation in inducing inflammation and insulin resistance, particularly stimulated by saturated fats.

Acknowledging limitations in his earlier work, Dr. Bikman transitions to discussing fat digestion and absorption, setting the stage for studies on the impact of dietary saturated fat on metabolic outcomes. He cites a study by Volk et al. (2014) contradicting the direct link between dietary saturated fat intake and plasma saturated fat levels. Further, he discusses research challenging the low-fat emphasis of diets like DASH, including a study by Chiu et al. (2016) showing comparable blood pressure reduction with a high-fat version.

The lecture also covers a meta-analysis by Choi et al. (2020) supporting the benefits of ketogenic diets high in saturated fat for glycemic control and insulin resistance.

Dr. Bikman emphasizes the importance of considering context, suggesting that saturated fat consumption without excessive carbohydrate intake may not necessarily lead to insulin resistance. However, he acknowledges studies indicating potential concerns with high saturated fat intake in hypercaloric, high-carb diets, advocating for balanced macronutrient consumption.

#InsulinResistance #SaturatedFat #MetabolicHealth #NutritionScience #HealthEducation #DietaryMyths #CellBiology #ResearchInsights #FatDigestion #KetogenicDiet #CardiometabolicHealth #DASHDiet #Inflammation #MedicalResearch #HealthDebunked

00:01 - Introduction of the topic of saturated fat and insulin resistance, highlighting common misconceptions and his expertise in the field.
02:33 - Role of TLR4: Research on toll-like receptor four (TLR4) activation and its connection to inflammation and ceramide synthesis, leading to insulin resistance.
07:05 - Fat Digestion Primer: Explanation of fat digestion in the small intestine, emphasizing the formation of chylomicrons for fat transport into the bloodstream.
11:55 - Study by Volk et al. (2014): Key study that challenges the idea of dietary saturated fat directly increasing plasma saturated fat levels, despite high consumption.
16:41 - High-Fat DASH Diet Study: Research comparing a high-fat version of the DASH diet to the standard low-fat version, highlighting similar blood pressure reduction but improved lipid profiles with the high-fat diet.
19:46 - Meta-analysis by Choi et al. (2020): Demonstrating the benefits of ketogenic diets, typically high in saturated fat, in improving glycemic control and insulin resistance.
21:40 - Historical Trends: The paradox of decreasing saturated fat consumption over time while insulin resistance rates have increased, suggesting a more complex relationship.
25:58 - Overfeeding Studies: Studies showing that overconsumption of carbohydrates, particularly refined sugars and starches, can increase liver fat and saturated fat production, contributing to insulin resistance.
27:09 - Study by Luukkonen et al. (2018): Study indicating that in a hypercaloric, high-carb diet, high saturated fat intake may worsen insulin resistance compared to high unsaturated fat intake.
28:06 - Conclusion: The need for nuanced understanding, context, and critical appraisal of research findings regarding the relationship between saturated fat, carbohydrate intake, and insulin resistance.

www.insuliniq.com/

www.jci.org/articles/view/57144

pubmed.ncbi.nlm.nih.gov/26718414/

journals.plos.org/plosone/article?id=10.1371/journ…

www.ncbi.nlm.nih.gov/pmc/articles/PMC7400909/

consensus.app/papers/glycogen-storage-capacity-lip…

consensus.app/papers/shortterm-carbohydrate-overfe…

diabetesjournals.org/care/article/41/8/1732/36380/…

All Comments (21)
  • @carolynhunt7333
    My granddaughter is headed off to medical school after having just graduated from BYU. I’m so happy that Dr. Bikman was her endocrinology professor. She’ll be a better doctor for having had his instruction.
  • And speaking of Calgary... Hi from Calgary! Now, can you give my doctor a call? He's in a PANIC because my LDL is through the roof since I went all Keto last August. In my lifetime, I've lost more than 300 pounds. After being treated for t-2 diabetes for 30 years, I almost lost my foot in Nov 2022. The following August, I came across Dr. Pradip Jamnadas, who eloquently explained it. I did everything he and so many others have said, I cut out high carbs, processed food, and seed oil, lost 70 pounds, triglycerides way down, HDL up and LDL really up a complete reversal of t2 diabetes A1C of 5.7... after all of that. He wants me on a staten and to stop consuming saturated fat. Hello, news desk, I think I found the problem.
  • Professor Bikman your hard work is very much appreciated. You have changed my life for the better, I can't thank you enough.
  • Dear Dr Bikman Thank you for clearing up all the falsehoods and proving that millions of people have suffered for decades due to the greed of big pharma
  • @akhusal
    Dr David Unwin gave the advice to his patients to eat plenty of saturated fat, meat, eggs and salt but avoid carbohydrates (bread, rice pasta, bananas, apple etc). Hundred patients lost weight, improved liver and kidney function, came off diabetes medications saving £70,000 in medicine costs for ten years. He recorded all stats over several years and published them in journals. If only every Doctor would do their job and above all first do no harm (conventional practice results in amputations, heart/kidney failure etc).
  • @johnwoodard8717
    About 2 1/2 years ago when i was diagnosed with T2 Diabetes my A1C was 10.4. I went on the lowest dose of metformin possible and went on a low carb high fat diet. 3 months later my A1C was 5.4. The only time it went up was when I was eating Mission Low Carb Tortillas regularly (they're a lie; a glucose test showed my blood glucose spiked to 154 just from eating one). My A1C went to 5.7, but more relevant to this conversation is that my Triglycerides spiked to 320. Cutting those out, 3 months later my A1C was 5.4 again and my Triglycerides were 128. 3 months after that they were 99. I didn't change anything else about my diet. Today I'm at 5.4-5.5 with no medication at all, and I'm not super-militant about my diet but I do avoid GPS (Grains, Potatoes, and Sugars) pretty heavily.
  • @meatdog
    Thanks a million times over. I am down this rabbit hole and cannot get enough of this education you are providing. I wish I could turn back my clock and pursue this research as my lifes work, also. Your contribution is priceless and I hope you are able to continue for a very long time. I read your book from cover to cover on Saturday and just could not put it down. I will be studying and subsuming it until the pages wear out. Sincerely.
  • @Neihlos
    What a fantastic way to start a Tuesday.
  • @salobrena6442
    I feel like a superstar now.. vldl is 14, ldl is 191, hdl 102.3 and my triglycerides are 71.. this was after 1 year on carnivore. This diet works and improves nearly every single thing. Even my car is running better.
  • @smthB4
    What an irony! Saturated fats are to blame after all, but not dietary saturated fat, rather saturated fat made from excess carbohydrates as a result of dietary guidelines! My ‘model’ of insulin resistance has just taken a couple of steps forward thanks to learning this 😊
  • @paulhailey2537
    Eating a Tasty Ribeye at this very moment with a couple Eggs too
  • @notsatch
    My scrambled eggs and sausage, fried in ghee, tastes even better than usual this morning!
  • @kriscook2449
    Thanks, Professor Bikman. You have expertly conveyed your message with your careful choice of words. You ROCK!
  • On a keto diet I eat huge amounts of saturated fat through bacon, red meat, eggs etc. and my triglycerides are ROCK bottom at 43 and HDL is a VERY healthy 84 and my waste circumference is 34. Take that food industry that's forever trying to hook me on carbs!
  • In an amazing way, you break down all that science and make it clear to everyone. I love your podcasts. keep going, Dr. All respect 🙏
  • @PL.Borneo
    The last study where saturated fat is combined with hypercaloric high carb diet brings to mind the Randle cycle where there’s a danger in combining fat and sugars together.
  • @CarnivoreScott
    Fat Tuesday is the BEST day of the week!! Thank you Dr. Bikman. Oh and the glasses ROCK! I'd like to say you DASH'd my hopes, but in truth you have once again reinforced the idea of how a proper human diet includes saturated fats. Well done, and THANK you for providing links to the quoted studies.
  • it is a Privilege to listen to Mr. Bikman 🍀👍
  • @JMK-vo8pv
    Two years ago I consulted a "preventive" cardiologist for my diabetes and known coronary artery disease. He just about threw me out his office when I told him I was considering a "ketogenic" diet. Then he went on to say I needed to be on a "plant based" diet, preferably the "Mediterrranean" diet, and that I needed to immediately embark on regular injections of PCSK9 inhibitors. Unfortunately, I believe that my experience is NOT rare. Thank goodness we have great scientists like Dr. Ben Bikman to set the record straight and help us progess toward better metabolic health!:medal-yellow-first-red:
  • @pinanay
    As a cell biology major in college and a med school dropout, I have thoroughly enjoyed this lecture. Thank you, Dr. Bikman. I have subscribed to your channel.