Janet Kelso: Archaic Genomics
64,098
Published 2020-05-26
Abstract:
Recent technological advances have made it possible to recover genome sequences from a number of archaic and early modern humans. These genomes offer a unique opportunity to explore the population histories of modern and archaic human groups and have provided direct evidence for interbreeding between early modern and archaic humans.
As a result, all present-day people outside of Africa carry approximately 2% Neandertal DNA, and some populations, largely in Oceania, also carry DNA from Denisovans. This introgressed DNA has been shown to have both positive and negative outcomes for present-day carriers: underlying apparently adaptive phenotypes as well as influencing disease risk.
In recent work, we have identified Neandertal haplotypes that are likely of archaic origin and determined the likely functional consequences of these haplotypes using public genome, gene expression, and phenotype datasets. We have also used simulations, as well as the distribution of Neandertal DNA in ancient modern humans, to understand how selection has acted on Neandertal introgressed sequences over the last 45,000 years.
All Comments (21)
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I have reviewed much of the material available on YouTube related to human genomics before seeing your presentation. I was very impressed with how much new information you presented to me in this one talk. Thank you.
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This was a spectacular talk. Thank you Janet Kelso!
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The text to speach has no idea what a Denisovan is. So far it has tried Dissident, Dennis of a cave, geniuses, Dennis Evans, dentist decay, Denise Oven I can't stop giggling, which is frustrating, because her talk is fascinating!
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Thank you indeed Dr. Kelso for this impressive and illustrative talk.
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Best thing I've ever seen on YouTube.
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Fascinating.
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Omg ..Thank u soooooo much Janet Kelso ...🙏💜
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Are the p values on the slide "traits associated with introgressed Neandertal variants" corrected for scanning?
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Absolutely fascinating I recently got a DNA reading so I'm not as lost as I would have been before I received it . I've always found ancient civilization fascinating and I've a keen interest in the Desanovians Thanks so much for this 😍
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Extremely interesting, thanks for sharing it with us.
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👍👍👍👍. Excellent presentation
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Small correction for youtu.be/jfLt5F7cyJw?t=583. It's not "Altai region of the Russian Caucasus", it is just Altai mountains. The Caucasus is where Mezmaiskaya cave is on the next slide.
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The Neanderthal mitochondria has been a big question. Thanks for the post.
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Thinking your doing great work for future reference. This may help with new medication and other understandings human immunity and growth of mutations.
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Fascinating, that we can discover a whole new hominid from the tiny bone of a pinky finger. What else will we find?
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This lady is incredibly knowledgeable, intellectual and very worthwhile listening too - if you can keep up. I'm an English native speaker but she speaks like a machine gun. I've switched off after 10 minutes, it's too stressful.
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way underrated video!!!
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Fascinating, thanks.
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As far as determining Neanderthal phenotype, wouldn't this suggest that they varied in phenotype to a similar degree that modern Eurasians do? Different phenotypes being selected in different regions for various reasons?
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what about the gene flow between Australian Aborigines and Denisovans? that should be higher
