Penicillin and Antibiotic Resistance (from PDB-101)

RCSBProteinDataBank
RCSBProteinDataBank
153,735
37
Published 2019-02-15
Since its discovery in 1928, penicillin and penicillin-related antibiotics helped save countless lives from bacterial infections. However, in the face of overuse and misuse of antibiotics, bacteria evolved resistance mechanisms that allow them to proliferate even in the presence of the newest antibiotics. Watch this video to learn how penicillin and penicillin-related antibiotics disrupt the bacterial life cycle, and what molecular mechanisms bacteria employ to evade the action of these drugs.

Learn more about antibiotic resistance from PDB-101 pdb101.rcsb.org/browse/antimicrobial-resistance

Story by: Stephen K. Burley, David S. Goodsell, Maria Voigt
Animation and Video Editing: Maria Voigt
Narration: Brian Hudson
All Comments (21)
  • @geoggernaut
    the squishy sounds really made me realize the importance of antibiotic resistance in a molecular level
  • @shihyonseo7314
    The video made so much sense. The graphics and the sound effects made it so much easier to understand how penicillin works. Thank you for a great video!
  • @desireemartin3303
    I am so grateful to share the animation with my students, so they may see the mechanics of macromolecules in action through bonding.
  • @kummer45
    This work is of institutional proportions. From these new scientists will understand problems faster due to the detailed explanations with the animations.
  • @adabujiki
    Seriously this is mind blowing .. i could watch 3 hours of this. How did they find out these details ??? This is bleeding edge bio chemistry.. and this guy and his voice drive this home!!! The detailed explanations, graphics OMG!! Imma fan
  • @ideoformsun5806
    I hope we can learn to use bacteriophage therapy more. It's targeted to a specific bacterium, and leaves the rest of the microbiome. I wonder if then we could cycle antibiotics in and out of use to retain their novelty. I wonder if antibiotics affect mitochondria.