CRISPR in Context: The New World of Human Genetic Engineering

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2019-10-26に共有
It’s happened. The first children genetically engineered with the powerful DNA-editing tool called CRISPR-Cas9 have been born to a woman in China. Their altered genes will be passed to their children, and their children’s children. Join CRISPR’s co-discoverer, microbiologist Jennifer Doudna, as we explore the perils and the promise of this powerful technology. It is not the first time human ingenuity has created something capable of doing us great good and great harm. Are we up to the challenge of guiding how CRISPR will shape the future?

PARTICIPANTS: Jennifer Doudna, Jamie Metzl, William Hurlbut

MODERATOR: Guy McKhann

MORE INFO ABOUT THE PROGRAM AND
PARTICIPANTS: www.worldsciencefestival.com/programs/crispr-conte…

TOPICS
0:00 - Introduction
1:55 - Jennifer Doudna introduction
2:25 - How do we learn to use CRISPR technology wisely?
3:29 - The basics of understanding CRISPR
6:04 - Genetic engineering explainer film
7:39 - How can CRISPR help the worldwide food chain?
9:57 - Genetic disease treatment
14:25 - Improving quality of life
15:55 - Designer babies
17:55 - The gene drive
19:25 - Confronting the ethical implications of CRISPR
23:55 - Jennifer’s childhood in Hawaii
28:25 - Patents
32:08 - Importance of accuracy
32:40 - Germ cells vs somatic cells
35:58 - He Jiankui controversy
40:05 - What makes CRISPR dangerous?
43:48 - How do we enforce regulation of CRISPR use?
53:50 - The aftermath of He Jiankui’s work
1:09:25 - How do we make CRISPR technology accessible globally?
1:14:00 - How do we balance natural biology and CRISPR?
1:18:44 - How will CRISPR impact our future as a species?

PROGRAM CREDITS
- Produced by Nils Kongshaug
- Associate Produced by Emmalina Glinskis
- Music provided by APM
- Additional images and footage provided by: Getty Images, Shutterstock, Videoblocks.
- Recorded at the Simons Foundation's Gerald D. Fishbaum Auditorium

The Kavli Prize recognizes scientists for their seminal advances in astrophysics, nanoscience, and neuroscience. The series, “The Big, the Small, and the Complex,” is sponsored by The Kavli Foundation.

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コメント (21)
  • @dewildest
    I am 35 years old and I feel healthier now than I did in my early 20's. See what happened was I gave up alchohol, increased my water and organic food intake, took up yoga and meditation. Now I don't get sick (like ever), and haven't been to a doctor in years. Our bodies are more capable than we could ever imagine.
  • I notice the debate stuck mostly to the implications of human gene manipulation and only briefly touch on plants and animals which with much thinner ethical veils on both are the more immediate threat. Also the advances in analytical AI systems could greatly accelerate advances in genetic manipulation to the point of it spiraling well out of our control.
  • My concerns would be the manipulation of DNA by organizations like world health organization, big Pharma, militarily industrial complex. Those who serve their own agenda and not the best interests of mankind.
  • @bunk2000
    After taking university genetics and molecular biology courses, I see genetics as so freaking complicated in terms of regulation, repair mechanisms, differential gene expression, robustness, etc, etc that I can't imagine the scenario people are freaking out about with designer babies or super-human soldiers. So much of genetics is not understood, not just about specific traits, but about how pathways operate. And much of genetic engineering in a lab is shooting in the dark and hoping a certain percent of your attempts were successful. It's extraordinarily difficult to edit single nucleotides or drop whole exons in precise targeting. As far as CRISPR itself, the machinery could bind to other locations within the genome and act at a non-target site (yay, unintended consequences) because CRISPR complexes target relatively small sequence domains. Hell, even introducing CRISPR reagents into the tissue of interest is a challenge (no, it won't just jump across the plasma membrane at the will of the scientist). Precision medicine is the future. It is so exciting that people with a range of conditions can soon have higher quality of and potentially extended lifespans. Until we all become educated enough on the technology, we can't begin to understand its implications- so until then, how about focus on how much suffering will be (and already has been!) reduced.
  • When she mentioned the WHO right out the gate ,fear shot right through me.
  • Pandora's box wide open and Klaus Schwab drooling 🤤 with excitement to compelling the World into hybridisation dystopia.
  • In a book about this, they document that she says her fear is the unethical use of the technology, especially in countries that have no moral qualms - she specifically states China. And then we had the Wuhan incident...
  • You should see what they are putting in our atmosphere here in Alberta and BC.
  • This woman comes off as infomercial host and cheerleader for The Who.
  • 44:25- "and the scientists have done an incredibly great job of being responsible". Well, that is all I needed to hear. Press on, Dr. Frankenstein.
  • @E-Kat
    I'm so grateful that there's no background music once the program starts properly. Thank you.🥀
  • I find it interesting that the SARS cov 2 💉 has crispr “cas 9” as the tool that helps insert the spike protein 🤔
  • @87gob54
    The World Health Organization Is favored by this woman. That easily tells us humans who's side she is on. Her own.
  • Romans 1:22 Professing themselves to be wise, they became fools,
  • @cog1140
    Hopefully we can eliminate the psychopathic and narcissistic gene out of those who live a life of excess thru the use of other people via deception and lies, for their own gain.
  • BRAVO! This video is a must view for classroom and public discussions. It could be edited down for time saving. One a scale of 1 to 10...it is a 12!
  • I wondering what nightmares she's having now, with the fact that the covid Vax has crisper technology Never mind, just discovered she is intimately connected with the WEC and covid testing using crispr........
  • How come any/all "NEW " scientific discoveries that claim to "BENEFIT" the human race NEVER end up beneficial to anyone other then a select few ?
  • @yellowjag
    Dr. Doudna, Way back in 1971 when I was in collge and majoring in Psycy an Biochem a professor asked me what I was going to do with it. I said well, the first thing we have to do is figure out how genes and chronosomes are related to disease and maybe behaviour. The professor at a SF Bay Area college said - You are wasting your time, there is no way we can get into anything as small as a gene or chronosome, go home and have babies and forget about it. Uh hum, sure thing. I kept following the field and 10 years later Dr.J, Craig Vinter did exactly what I said we needed to do. It took him 13 years, but he came up with the hardware and software and everything needed to sequence genes which didn't exist at the time the professor told me It couldn't be done. I've since kept following the field and reading about the Tumor Suppressor gene in relation to cancer - my cool big brother died of cancer a while back and I have a question for you. I understand genes are binary, either on or off. If that is so can't we turn the TSG on by crispering out the mutated sequence and replacing it with the correct sequence that turns the tumor suppressor gene on.?