Managing Side Effects of Thiamine Supplementation: The Paradoxical Reaction

I just want to go back to 1962 where everything was simple you didn't have to be a scientist to wake up and feel good everyday

Thiamine megadosing cured my covid long haul syndrome in five days. I literally went from being bedridden to my normal self in under a week. It truly was a miracle!

It's been 3 weeks since I started a Thiamine Mega dose and WOW! It made a huge difference. It's like my gut all of a sudden decided to start working again! I worked up to 1200mg Benfotiamine, Creatine as a methyl loaner, potassium iodine & selenium, molybdenum and Glutathione for support.

0:00 - Introduction 2:05 - Key Points 3:33 - Other B vitamins 4:58 - Electrolytes 10:28 - Glutathione 15:41 - Methylation 20:42 - Sulfoxidation 23:09 - Conclusion

I suffer from a tbi that happened approximately 33 years ago. Part of my brain is actually dark matter. How I can function normally is beyond me. However, I have been diagnosed with severe depression, anxiety, and panic attacks….As well as being exhausted all the time. I came across your videos today and I am beyond ecstatic this might help with some of my health issues. Time for a little experimenting!! Can’t thank you enough for your videos!!

Level 10 Brilliant. Elliot is a genius for this type of information. Bless him!

Thank you so much for this information Elliot. I started to increase thiamine a few days ago, and have started to experience those symptoms. Good to know what it is and why. Very grateful for your incredible knowledge.Thank you😀

Genius.. This video filled in all the blanks I had about Thiamine and it's derivatives. THANK YOU!!

Elliot, appreciate all your work. These are great information. Wishing you a loooooong & happy life.

This is great information but also extremely overwhelming for the laymen who wants to start a protocol to heal. I have gut issues, possibly SIBO, and tend to be super sensitive to taking anything new and there are so many options for supplements that might be beneficial with TTFD that I don't even know where to start!

Take a high quality B COMPLEX and most of your risk will be gone. Add some magnesium, some "low salt" (i.e. potassium salt) and high-selenium foods and you're set.

Man your work on thiamine has changed my life. Thank you man! Glad you're back.

Holy crap, I'm SO CONFUSED!! Here I thought there was hope for me, and that B1 might be the answer, but this video is so over my head and now I'm more confused than ever. I guess i won't be trying this anytime soon 😭

So interesting. Thank you. I'm chronically ill and at my worst I was bedridden for 8 years. I was trying for years (3) to take folate. I couldn't get above a crumb without debilitating side effects, and yet, I'd developed folate related anemia (megaloblastic). Last year the doctor didn't listen to me at that appointment and wrote a script for a high dose of Folic Acid. I threw that out because I have a homozygous MTHFR mutation. Within a week or so it dawned on me (by stumbling onto some information) that, despite having normal blood serum levels of magnesium, I was deficient. I started supplementing (had avoided magnesium supplementation because I have CKD - idiopathic... likely from chronic folate deficiency) and immediately could take whatever amount of Folate I wanted. My health improved a tiny bit. (I've tried benfotiamine and haven't found it helpful, though I'm still taking 100mg a day.) Have just stumbled onto to the thiamine connection and given my past history, including things that helped me get better but were compounded by too many variables at the time for me to sort out what had and hadn't helped, and defects in TPP (loads of homozygous TPK-1 mutations), transketolase mutations, and a couple of mutations associated with Thiamine-Responsive Megaloblastic Anemia Syndrome and Thiamine Metabolism Dysfunction Syndrome 5, this makes perfect sense. I also have mutated SLC19A3 genes - out of 17 SNPS two are homozygous mutations, four are heterozygous, and with three there's not enough information. I've also had a very slow heart rate and low blood pressure all of my life and ridiculously slow rate in recent years (in the 30s and lower 40s). Diagnosed with multiple chemical sensitivities and ME/CFS... a lot of the symptoms of Beri Beri fit with that. I'd looked at wet Beri Beri before (given heart symptoms that show up as nothing) but thought, "Surely a doctor would have considered this." I could still have ME/CFS (I have 5 mutations of a gene that people who are severe with ME/CFS typically have 3 - yet, ME/CFS can happen to almost anyone as the mutations are common), but this looks promising and I have supplements on order. I also wonder if so many of us with ME/CFS who have had very slow onset aren't deficient in thiamin. I don't have potassium wasting because I take olmesartan which is potassium sparing and between that and an ACE mutation, I have to watch my potassium. So, I'm good there. I have to take sodium because of that and because I have unexplained salt wasting (a little known symptom of a thiamine deficiency can be salt wasting). I'm thinking of going off of olmesartan because it increases my fatigue. I'm also diagnosed autistic and to be fair I have genes for the same. Some of the B1 genes that are mutated are also related to a biotin deficiency and based on my nails and how much biotin I take just to keep them from painfully tearing and splitting, my body's doing a poor job with that vitamin as well (they've gotten a bit better with my being able to consume folate). Hopefully, thiamin can help with that process. I'm in my mid 60s and have been noticeably unwell and without stamina since I was 8 and was the working sick until I became seriously ill / disabled 19 years ago. When you've been this sick for so long, it feels dangerous to have hope, but I am hopeful. I am so glad I stumbled onto information about this and your video.

Great work E.O., yesterday I increase Benfotiamine from 500 mg to 1000 mg and I experienced many of the side effects You mention here the symptoms subsided after I took NAC 600mg , the major difference in my protocol was the absence of CDP coline that I was taking regularly and also the addition of a probiotic suppliment, so I will be adding potassium rich food and a mythyl door suppliment, thanks for sharing appreciated 👍👍👍!!!

Thank you 🙏 Melatonin helps to recycle GSSH to GSH and other products of oxidative stress. Probably could lower the paradoxical effect.

Very very helpful. Explains so much of my difficulties and what to watch when raising benfotiamine. THANK YOU.

I slowly started this.. and slowly highten the dose.. no probs here, just positive effects.(Chronic Lyme and co) Thank You for this info about thiamine.. its greatly improved my life in ALL ways❣️😌👌🏼.. much Love 👋🏼☺️🇸🇪

Elliott, this is such a special channel!

thank you for using your intelligence for greater good, this information is gold.